| Aug 18, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $41.81 | $238K |
| Aug 10, 2026 | Robert Blum | PRESIDENT & CEO | SELL-OPTIONS | — | $43.68 | $496K |
| Jul 30, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $51.57 | $793K |
| Jul 27, 2026 | Robert Blum | PRESIDENT & CEO | SELL-OPTIONS | — | $45.73 | $527K |
| Jul 21, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $44.20 | $255K |
| Jul 13, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 10.000 | $46.31 | $536K |
| Jul 7, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $47.21 | $276K |
| Jul 1, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $84.92 | $637K |
| Jul 1, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $54.53 | $938K |
| Jul 1, 2026 | Sung Lee | EVP, CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $68.15 | $44K |
| Jun 29, 2026 | Sung Lee | EVP, CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $65.42 | $123K |
| Jun 24, 2026 | Sung Lee | EVP, CHIEF FINANCIAL OFFICER | SELL-OPTIONS | — | $64.70 | $1.4M |
| Jun 23, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $43.66 | $251K |
| Jun 15, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $70.46 | $528K |
| Jun 9, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $37.89 | $211K |
| Jun 1, 2026 | Dr. Kaye | DIRECTOR | SELL | 2.933K | $76.09 | $223K |
| Jun 1, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $48.67 | $762K |
| Jun 1, 2026 | LYNNE PARSHALL | DIRECTOR | SELL | 5.000K | $74.08 | $370K |
| May 27, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $77.21 | $579K |
| May 19, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $41.74 | $238K |
| May 14, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $77.92 | $584K |
| May 5, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $42.59 | $243K |
| May 5, 2026 | Dr. Wierenga | DIRECTOR | SELL-OPTIONS | — | $43.70 | $252K |
| May 5, 2026 | Sung Lee | EVP, CHIEF FINANCIAL OFFICER | SELL | 23.906K | $76.87 | $1.8M |
| May 5, 2026 | Dr. Henderson | DIRECTOR | SELL-OPTIONS | — | $41.79 | $1.4M |
| May 5, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $58.19 | $432K |
| May 1, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $51.31 | $434K |
| Apr 30, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $43.26 | $600K |
| Apr 29, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $59.62 | $447K |
| Apr 21, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $36.74 | $203K |
| Apr 15, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 7.449K | $66.02 | $492K |
| Apr 15, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $65.38 | $490K |
| Apr 7, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL-OPTIONS | — | $36.77 | $255K |
| Apr 1, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.500K | $66.63 | $500K |
| Mar 31, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 3.639K | $65.00 | $237K |
| Mar 18, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 1.930K | $62.07 | $120K |
| Mar 17, 2026 | Sung Lee | EVP, CHIEF FINANCIAL OFFICER | SELL | 4.935K | $62.15 | $307K |
| Mar 17, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 8.542K | $62.15 | $531K |
| Mar 17, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL | 12.033K | $62.15 | $748K |
| Mar 17, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 36.601K | $62.15 | $2.3M |
| Mar 16, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 1.709K | $61.03 | $104K |
| Mar 9, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL | 2.582K | $60.72 | $157K |
| Mar 9, 2026 | Dr. Malik | EVP RESEARCH & DEVELOPMENT | SELL | 2.907K | $60.72 | $177K |
| Mar 9, 2026 | Robert Blum | PRESIDENT & CEO | SELL | 7.931K | $60.72 | $482K |
| Mar 5, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $45.92 | $829K |
| Mar 2, 2026 | LYNNE PARSHALL | DIRECTOR | SELL | 5.000K | $61.21 | $306K |
| Mar 2, 2026 | Andrew Callos | EVP, CHIEF COMMERCIAL OFFICER | SELL-OPTIONS | — | $49.63 | $21K |
