Market sentiment signals for Spyre Therapeutics (SYRE): analyst consensus, short interest, options flow and insider activity.
Analyst Consensus
Buy
20 analysts
Options Flow (P/C)
9.00
More puts — Bearish
Avg Consensus PT
$101
+25.9%
Highest Price Target
$130
+62.3%
Lowest Price Target
$44
-45.1%
Short Interest
14.6%
Declining — Bullish
Insider Activity (30d)
Net Seller
Short Interest — % of Float
| Date | Firm | Analyst & Accuracy | Upside / Downside | PT Change | Action | Rating |
|---|---|---|---|---|---|---|
| Oct 12, 2026 | UBS | Alice Nettleton— | +49.8% | $120 | Initiate | Buy |
| Oct 1, 2026 | JP Morgan | Hardik Parikh— | +37.3% | $110 | Initiate | Overweight |
