Aptiv (NYSE:APTV) 주식

Aptiv

Aptiv PLC signal and power solutions segment supplies components and systems that make up a vehicle's electrical system, including wiring assemblies and harnesses, connectors, electrical centers, and hybrid electrical systems. The operating segments are grouped on the basis of similar product, market and operating factors: Signal and Power Solutions, which includes complete electrical architecture and component products. advanced Safety and User Experience, which includes vehicle technology and services in advanced safety, user experience, and smart vehicle computing and software, as well as cloud-native software platforms, autonomous driving technologies, and DevOps tools. Eliminations and Other.

Prague,,Czech,Republic,08,27,2024:,Temu,App,Online,Marketplace

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Movers

Trading Ideas

APTV

BABA

CRWV

Citigourp Global Markets 2% Protected Notes Linked To The Djia

STLA

YUMC

PDD홀딩스·알리바바 등 미중 무역 긴장 속 지난주 급락한 대형주 10종목: 4월 7일부터 11일까지 지난주 최악의 실적을 기록한 대형주는 다음과 같다.

PDD홀딩스·알리바바 등 미중 무역 긴장 속 지난주 급락한 대형주 10종목 (4월 7일~11일)

Top 3 Stocks To Watch In 2025 According To Wall Street Bulls

RACE

TSLA

뱅크오브아메리카는 2025년에 실적이 개선될 것으로 예상되는 주요 자동차 주식 3종목으로 페라리(RACE), 앱티브(NYSE:APTV) 및 오토네이션(NYSE:AN)을 선정했다. 이들 기업은 최근의 변동성과 섹터 내 과제에도 불구하고 자동차 산업의 지속적인 추세로부터 혜택을 받을 수 있는 좋은 위치에 있다고 강조했다.

뱅크오브아메리카: 2025년 상승할 자동차 주식 3종목은?

Deal Dispatch

AAUKF

ATSG

streetTRACKS Dow Jones U.S. Large Cap Value Index Fund

FFIV

KRON

MEIP

NISTF

PARA

PARIS:SGO

ROIC

SAVE

SHEL

SLGWF

SLNG

TRIP

TSX:SGO

ULCC

새로 등장한 블록 에볼런트 헬스(NYSE:EVH)가 매물로 나온 것으로 알려졌다. 버지니아 주 알링턴에 본사를 둔 이 소프트웨어 회사는 인수 문의를 받은 후 경매 프로세스를 시작했다. 잠재적인 구혼자 중에는 TPG(NASDAQ:TPG), 클레이톤, 듀블리에 &amp; 라이스(Clayton, Dubilier &amp; Rice), KKR &amp; 컴퍼니(NYSE:KKR)가 있다. 로이터는 건강 보험사 엘레반스 헬스(NYSE:ELV)가 한 사모 펀드 파트너와 협력하여 거래를 추진할 수 있다고 보고했다.

딜 디스패치: 쉘, 유니레버 외에도 매각 뉴스; 어니언이 알렉스 존스의 인포워스 인수 등

Aptiv PLC

Needham analyst Gil Blum reiterates Taysha Gene Therapies (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSHA#NASDAQ">TSHA</a>) with a Buy and raises the price target from $6 to $8.

Price Target

Reiteration

Analyst Ratings

TSHA

Needham Reiterates Buy on Taysha Gene Therapies, Raises Price Target to $8

WIIM

Molina Healthcare shares are trading lower after Barclays maintained an Equal-Weight rating on the stock but lowered its price target from $362 to $351.

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders often look for circumstances when the market estimation of an option diverges away from its normal worth. Abnormal amounts of trading activity could push option prices to hyperbolic or underperforming levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>GE</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/18/25</td>
<td>$240.00</td>
<td>$228.0K</td>
<td>6.9K</td>
<td>2.1K</td>
</tr>
<tr>
<td>SMR</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$32.00</td>
<td>$27.0K</td>
<td>309</td>
<td>1.1K</td>
</tr>
<tr>
<td>RKLB</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>06/20/25</td>
<td>$25.00</td>
<td>$91.0K</td>
<td>11.2K</td>
<td>895</td>
</tr>
<tr>
<td>BA</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>01/15/27</td>
<td>$250.00</td>
<td>$62.1K</td>
<td>200</td>
<td>465</td>
</tr>
<tr>
<td>AAL</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>09/19/25</td>
<td>$11.00</td>
<td>$31.6K</td>
<td>8.4K</td>
<td>369</td>
</tr>
<tr>
<td>ZIM</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>01/16/26</td>
<td>$19.16</td>
<td>$79.9K</td>
<td>28.3K</td>
<td>187</td>
</tr>
<tr>
<td>UAL</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/20/25</td>
<td>$82.00</td>
<td>$36.2K</td>
<td>198</td>
<td>169</td>
</tr>
<tr>
<td>CAR</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/18/26</td>
<td>$105.00</td>
<td>$32.4K</td>
<td>300</td>
<td>19</td>
</tr>
<tr>
<td>GEV</td>
<td>CALL</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>07/18/25</td>
<td>$450.00</td>
<td>$30.8K</td>
<td>541</td>
<td>18</td>
</tr>
<tr>
<td>GWW</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>01/16/26</td>
<td>$1070.00</td>
<td>$51.0K</td>
<td>0</td>
<td>6</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These itemized elaborations have been created using the accompanying table. 
• For GE (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GE#NYSE">GE</a>), we notice a put option sweep that happens to be bearish, expiring in 46 day(s) on July 18, 2025. This event was a transfer of 300 contract(s) at a $240.00 strike. This particular put needed to be split into 19 different trades to become filled. The total cost received by the writing party (or parties) was $228.0K, with a price of $760.0 per contract. There were 6902 open contracts at this strike prior to today, and today 2111 contract(s) were bought and sold. 
• Regarding SMR (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SMR#NYSE">SMR</a>), we observe a call option sweep with bullish sentiment. It expires in 74 day(s) on August 15, 2025. Parties traded 45 contract(s) at a $32.00 strike. This particular call needed to be split into 12 different trades to become filled. The total cost received by the writing party (or parties) was $27.0K, with a price of $600.0 per contract. There were 309 open contracts at this strike prior to today, and today 1177 contract(s) were bought and sold. 
• For RKLB (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RKLB#NASDAQ">RKLB</a>), we notice a call option trade that happens to be bearish, expiring in 18 day(s) on June 20, 2025. This event was a transfer of 353 contract(s) at a $25.00 strike. The total cost received by the writing party (or parties) was $91.0K, with a price of $258.0 per contract. There were 11206 open contracts at this strike prior to today, and today 895 contract(s) were bought and sold. 
• For BA (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BA#NYSE">BA</a>), we notice a put option sweep that happens to be bullish, expiring in 592 day(s) on January 15, 2027. This event was a transfer of 12 contract(s) at a $250.00 strike. This particular put needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $62.1K, with a price of $5184.0 per contract. There were 200 open contracts at this strike prior to today, and today 465 contract(s) were bought and sold. 
• Regarding AAL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAL#NASDAQ">AAL</a>), we observe a put option sweep with bullish sentiment. It expires in 109 day(s) on September 19, 2025. Parties traded 316 contract(s) at a $11.00 strike. This particular put needed to be split into 11 different trades to become filled. The total cost received by the writing party (or parties) was $31.6K, with a price of $100.0 per contract. There were 8439 open contracts at this strike prior to today, and today 369 contract(s) were bought and sold. 
• For ZIM (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ZIM#NYSE">ZIM</a>), we notice a put option sweep that happens to be bullish, expiring in 228 day(s) on January 16, 2026. This event was a transfer of 186 contract(s) at a $19.16 strike. This particular put needed to be split into 24 different trades to become filled. The total cost received by the writing party (or parties) was $79.9K, with a price of $430.0 per contract. There were 28300 open contracts at this strike prior to today, and today 187 contract(s) were bought and sold. 
• Regarding UAL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/UAL#NASDAQ">UAL</a>), we observe a call option sweep with bearish sentiment. It expires in 18 day(s) on June 20, 2025. Parties traded 139 contract(s) at a $82.00 strike. This particular call needed to be split into 15 different trades to become filled. The total cost received by the writing party (or parties) was $36.2K, with a price of $261.0 per contract. There were 198 open contracts at this strike prior to today, and today 169 contract(s) were bought and sold. 
• For CAR (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CAR#NASDAQ">CAR</a>), we notice a put option sweep that happens to be bullish, expiring in 381 day(s) on June 18, 2026. This event was a transfer of 17 contract(s) at a $105.00 strike. This particular put needed to be split into 4 different trades to become filled. The total cost received by the writing party (or parties) was $32.4K, with a price of $1910.0 per contract. There were 300 open contracts at this strike prior to today, and today 19 contract(s) were bought and sold. 
• For GEV (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GEV#NYSE">GEV</a>), we notice a call option trade that happens to be neutral, expiring in 46 day(s) on July 18, 2025. This event was a transfer of 6 contract(s) at a $450.00 strike. The total cost received by the writing party (or parties) was $30.8K, with a price of $5138.0 per contract. There were 541 open contracts at this strike prior to today, and today 18 contract(s) were bought and sold. 
• For GWW (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GWW#NYSE">GWW</a>), we notice a call option trade that happens to be bullish, expiring in 228 day(s) on January 16, 2026. This event was a transfer of 6 contract(s) at a $1070.00 strike. The total cost received by the writing party (or parties) was $51.0K, with a price of $8500.0 per contract. There were 0 open contracts at this strike prior to today, and today 6 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Options

RKLB

10 Industrials Stocks With Whale Alerts In Today's Session

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders will search for circumstances when the market estimation of an option diverges heavily from its normal worth. High amounts of trading activity could push option prices to exaggerated or underestimated levels. 
Below are some instances of options activity happening in the Consumer Discretionary sector: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>TSLA</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/06/25</td>
<td>$360.00</td>
<td>$69.4K</td>
<td>13.4K</td>
<td>45.9K</td>
</tr>
<tr>
<td>AMZN</td>
<td>PUT</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>06/06/25</td>
<td>$205.00</td>
<td>$65.7K</td>
<td>4.6K</td>
<td>5.1K</td>
</tr>
<tr>
<td>GME</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/18/25</td>
<td>$35.00</td>
<td>$45.9K</td>
<td>10.9K</td>
<td>1.5K</td>
</tr>
<tr>
<td>BABA</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>07/18/25</td>
<td>$115.00</td>
<td>$29.1K</td>
<td>4.0K</td>
<td>1.0K</td>
</tr>
<tr>
<td>SIG</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/06/25</td>
<td>$67.00</td>
<td>$36.8K</td>
<td>52</td>
<td>786</td>
</tr>
<tr>
<td>EAT</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$140.00</td>
<td>$26.0K</td>
<td>4.0K</td>
<td>583</td>
</tr>
<tr>
<td>DASH</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/13/25</td>
<td>$210.00</td>
<td>$40.9K</td>
<td>1.1K</td>
<td>488</td>
</tr>
<tr>
<td>HD</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$400.00</td>
<td>$26.1K</td>
<td>1.2K</td>
<td>156</td>
</tr>
<tr>
<td>CMG</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/16/26</td>
<td>$51.00</td>
<td>$50.9K</td>
<td>795</td>
<td>123</td>
</tr>
<tr>
<td>DKNG</td>
<td>PUT</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>08/15/25</td>
<td>$35.00</td>
<td>$37.5K</td>
<td>2.8K</td>
<td>103</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These itemized elaborations have been created using the accompanying table. 
• For TSLA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>), we notice a call option sweep that happens to be bullish, expiring in 4 day(s) on June 6, 2025. This event was a transfer of 250 contract(s) at a $360.00 strike. This particular call needed to be split into 23 different trades to become filled. The total cost received by the writing party (or parties) was $69.4K, with a price of $278.0 per contract. There were 13453 open contracts at this strike prior to today, and today 45900 contract(s) were bought and sold. 
• For AMZN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>), we notice a put option trade that happens to be neutral, expiring in 4 day(s) on June 6, 2025. This event was a transfer of 274 contract(s) at a $205.00 strike. The total cost received by the writing party (or parties) was $65.7K, with a price of $240.0 per contract. There were 4670 open contracts at this strike prior to today, and today 5167 contract(s) were bought and sold. 
• Regarding GME (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GME#NYSE">GME</a>), we observe a call option sweep with bearish sentiment. It expires in 46 day(s) on July 18, 2025. Parties traded 200 contract(s) at a $35.00 strike. This particular call needed to be split into 20 different trades to become filled. The total cost received by the writing party (or parties) was $45.9K, with a price of $230.0 per contract. There were 10926 open contracts at this strike prior to today, and today 1569 contract(s) were bought and sold. 
• For BABA (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>), we notice a put option trade that happens to be bullish, expiring in 46 day(s) on July 18, 2025. This event was a transfer of 47 contract(s) at a $115.00 strike. The total cost received by the writing party (or parties) was $29.1K, with a price of $620.0 per contract. There were 4089 open contracts at this strike prior to today, and today 1044 contract(s) were bought and sold. 
• For SIG (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SIG#NYSE">SIG</a>), we notice a call option sweep that happens to be bearish, expiring in 4 day(s) on June 6, 2025. This event was a transfer of 93 contract(s) at a $67.00 strike. This particular call needed to be split into 14 different trades to become filled. The total cost received by the writing party (or parties) was $36.8K, with a price of $384.0 per contract. There were 52 open contracts at this strike prior to today, and today 786 contract(s) were bought and sold. 
• For EAT (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EAT#NYSE">EAT</a>), we notice a put option sweep that happens to be bearish, expiring in 74 day(s) on August 15, 2025. This event was a transfer of 65 contract(s) at a $140.00 strike. This particular put needed to be split into 29 different trades to become filled. The total cost received by the writing party (or parties) was $26.0K, with a price of $400.0 per contract. There were 4031 open contracts at this strike prior to today, and today 583 contract(s) were bought and sold. 
• For DASH (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DASH#NASDAQ">DASH</a>), we notice a call option sweep that happens to be bearish, expiring in 11 day(s) on June 13, 2025. This event was a transfer of 65 contract(s) at a $210.00 strike. This particular call needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $40.9K, with a price of $630.0 per contract. There were 1167 open contracts at this strike prior to today, and today 488 contract(s) were bought and sold. 
• Regarding HD (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HD#NYSE">HD</a>), we observe a call option sweep with bearish sentiment. It expires in 74 day(s) on August 15, 2025. Parties traded 87 contract(s) at a $400.00 strike. This particular call needed to be split into 11 different trades to become filled. The total cost received by the writing party (or parties) was $26.1K, with a price of $298.0 per contract. There were 1290 open contracts at this strike prior to today, and today 156 contract(s) were bought and sold. 
• Regarding CMG (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CMG#NYSE">CMG</a>), we observe a call option trade with bearish sentiment. It expires in 228 day(s) on January 16, 2026. Parties traded 100 contract(s) at a $51.00 strike. The total cost received by the writing party (or parties) was $50.9K, with a price of $510.0 per contract. There were 795 open contracts at this strike prior to today, and today 123 contract(s) were bought and sold. 
• Regarding DKNG (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DKNG#NASDAQ">DKNG</a>), we observe a put option trade with neutral sentiment. It expires in 74 day(s) on August 15, 2025. Parties traded 100 contract(s) at a $35.00 strike. The total cost received by the writing party (or parties) was $37.5K, with a price of $375.0 per contract. There were 2846 open contracts at this strike prior to today, and today 103 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

AMZN

DASH

DKNG

10 Consumer Discretionary Stocks With Whale Alerts In Today's Session

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders often look for circumstances when the market estimation of an option diverges away from its normal worth. Abnormal amounts of trading activity could push option prices to hyperbolic or underperforming levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>NVDA</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/06/25</td>
<td>$137.00</td>
<td>$27.4K</td>
<td>11.3K</td>
<td>100.0K</td>
</tr>
<tr>
<td>RGTI</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/06/25</td>
<td>$13.00</td>
<td>$37.1K</td>
<td>1.9K</td>
<td>12.8K</td>
</tr>
<tr>
<td>MSFT</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/06/25</td>
<td>$462.50</td>
<td>$713.1K</td>
<td>984</td>
<td>10.0K</td>
</tr>
<tr>
<td>PLTR</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$160.00</td>
<td>$44.0K</td>
<td>6.3K</td>
<td>4.4K</td>
</tr>
<tr>
<td>KOPN</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>07/18/25</td>
<td>$1.50</td>
<td>$30.0K</td>
<td>2.3K</td>
<td>2.0K</td>
</tr>
<tr>
<td>INTC</td>
<td>CALL</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>08/15/25</td>
<td>$19.00</td>
<td>$77.6K</td>
<td>5.0K</td>
<td>1.5K</td>
</tr>
<tr>
<td>AVGO</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>06/06/25</td>
<td>$240.00</td>
<td>$28.0K</td>
<td>2.6K</td>
<td>1.0K</td>
</tr>
<tr>
<td>AMD</td>
<td>PUT</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>09/19/25</td>
<td>$110.00</td>
<td>$61.6K</td>
<td>14.5K</td>
<td>742</td>
</tr>
<tr>
<td>AAPL</td>
<td>PUT</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>06/13/25</td>
<td>$202.50</td>
<td>$25.4K</td>
<td>504</td>
<td>623</td>
</tr>
<tr>
<td>ARM</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$125.00</td>
<td>$74.5K</td>
<td>1.2K</td>
<td>582</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• For NVDA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>), we notice a call option sweep that happens to be bullish, expiring in 4 day(s) on June 6, 2025. This event was a transfer of 100 contract(s) at a $137.00 strike. This particular call needed to be split into 8 different trades to become filled. The total cost received by the writing party (or parties) was $27.4K, with a price of $274.0 per contract. There were 11350 open contracts at this strike prior to today, and today 100067 contract(s) were bought and sold. 
• Regarding RGTI (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGTI#NASDAQ">RGTI</a>), we observe a call option sweep with bearish sentiment. It expires in 4 day(s) on June 6, 2025. Parties traded 2101 contract(s) at a $13.00 strike. This particular call needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $37.1K, with a price of $18.0 per contract. There were 1956 open contracts at this strike prior to today, and today 12878 contract(s) were bought and sold. 
• Regarding MSFT (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSFT#NASDAQ">MSFT</a>), we observe a call option sweep with bearish sentiment. It expires in 4 day(s) on June 6, 2025. Parties traded 2228 contract(s) at a $462.50 strike. This particular call needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $713.1K, with a price of $320.0 per contract. There were 984 open contracts at this strike prior to today, and today 10077 contract(s) were bought and sold. 
• Regarding PLTR (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PLTR#NASDAQ">PLTR</a>), we observe a call option trade with bearish sentiment. It expires in 74 day(s) on August 15, 2025. Parties traded 55 contract(s) at a $160.00 strike. The total cost received by the writing party (or parties) was $44.0K, with a price of $800.0 per contract. There were 6351 open contracts at this strike prior to today, and today 4498 contract(s) were bought and sold. 
• Regarding KOPN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/KOPN#NASDAQ">KOPN</a>), we observe a call option trade with bullish sentiment. It expires in 46 day(s) on July 18, 2025. Parties traded 2000 contract(s) at a $1.50 strike. The total cost received by the writing party (or parties) was $30.0K, with a price of $15.0 per contract. There were 2316 open contracts at this strike prior to today, and today 2015 contract(s) were bought and sold. 
• For INTC (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INTC#NASDAQ">INTC</a>), we notice a call option trade that happens to be neutral, expiring in 74 day(s) on August 15, 2025. This event was a transfer of 353 contract(s) at a $19.00 strike. The total cost received by the writing party (or parties) was $77.6K, with a price of $220.0 per contract. There were 5072 open contracts at this strike prior to today, and today 1531 contract(s) were bought and sold. 
• For AVGO (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AVGO#NASDAQ">AVGO</a>), we notice a call option trade that happens to be bullish, expiring in 4 day(s) on June 6, 2025. This event was a transfer of 20 contract(s) at a $240.00 strike. The total cost received by the writing party (or parties) was $28.0K, with a price of $1402.0 per contract. There were 2677 open contracts at this strike prior to today, and today 1037 contract(s) were bought and sold. 
• Regarding AMD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMD#NASDAQ">AMD</a>), we observe a put option sweep with neutral sentiment. It expires in 109 day(s) on September 19, 2025. Parties traded 72 contract(s) at a $110.00 strike. This particular put needed to be split into 7 different trades to become filled. The total cost received by the writing party (or parties) was $61.6K, with a price of $856.0 per contract. There were 14522 open contracts at this strike prior to today, and today 742 contract(s) were bought and sold. 
• For AAPL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>), we notice a put option trade that happens to be bearish, expiring in 11 day(s) on June 13, 2025. This event was a transfer of 50 contract(s) at a $202.50 strike. The total cost received by the writing party (or parties) was $25.4K, with a price of $510.0 per contract. There were 504 open contracts at this strike prior to today, and today 623 contract(s) were bought and sold. 
• Regarding ARM (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ARM#NASDAQ">ARM</a>), we observe a put option sweep with bullish sentiment. It expires in 74 day(s) on August 15, 2025. Parties traded 65 contract(s) at a $125.00 strike. This particular put needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $74.5K, with a price of $1147.0 per contract. There were 1255 open contracts at this strike prior to today, and today 582 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

AAPL

AVGO

INTC

KOPN

MSFT

NVDA

PLTR

RGTI

10 Information Technology Stocks Whale Activity In Today's Session

Scotiabank maintains i-80 Gold (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/IAUX#AMEX">IAUX</a>) with a Sector Outperform and lowers the price target from $2.25 to $1.5.

IAUX

Scotiabank Maintains Sector Outperform on i-80 Gold, Lowers Price Target to $1.5

<a href="https://www.bloomberg.com/news/articles/2025-06-02/musk-s-xai-launches-5-billion-debt-sale-through-morgan-stanley" title="https://www.bloomberg.com/news/articles/2025-06-02/musk-s-xai-launches-5-billion-debt-sale-through-morgan-stanley">https://www.bloomberg.com/news/articles/2025-06-02/musk-s-xai-launches-5-billion-debt-sale-through-morgan-stanley</a>

GOOG

GOOGL

'Musk's xAI Launches $5 Billion Debt Sale Through Morgan Stanley' - Bloomberg News

Zscaler Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZS#NASDAQ">ZS</a>) shares are trading higher Monday on what appears to be continued momentum after the company posted better-than-expected fiscal third-quarter earnings and raised its <a href="https://www.benzinga.com/trading-ideas/movers/25/05/45700639/zscaler-stock-is-gaining-friday-whats-going-on">full-year guidance last week</a>.
What To Know: The cybersecurity firm reported adjusted earnings of 84 cents per share, beating analyst estimates of 75 cents per share and revenue of $678 million, which topped consensus forecasts of $666.86 million.
The results were driven by demand for Zscaler&#8217;s Zero Trust Exchange platform and increased customer adoption across its portfolio. Calculated billings climbed 26% year-over-year to $785 million, exceeding expectations. Annual recurring revenue (ARR) also grew 23% year-over-year to $2.9 billion.
Despite the positive results, Piper Sandler downgraded the stock to Neutral from Overweight, citing valuation concerns and potential risks tied to Zscaler&#8217;s recent Red Canary acquisition and federal sector uncertainty. Still, the firm raised its price target from $235 to $260.
Other analysts were more bullish. RBC, KeyBanc, Needham and Rosenblatt all increased their price targets, with Rosenblatt pushing its forecast to $315. Analysts highlighted Zscaler&#8217;s strong execution, growing momentum in key product areas like Zero Trust and AI-driven security and improving sales productivity. Several firms also noted the company did not report any negative impact from current tariffs, a positive sign in the current macro environment. Positive analyst changes continue to roll in this week with Canaccord Genuity lifting its target from $230 to $305.
Zscaler's management raised full-year 2025 revenue guidance to a range of $2.659 billion to $2.661 billion, slightly above analyst estimates. Full-year adjusted earnings are now expected to be between $3.18 and $3.19 per share, up from prior forecasts and well ahead of the Street&#8217;s $3.07 estimate.
ZS Price Action: Zscaler shares were up 5.89% at $291.94 at the time of writing. Zscaler shares are now up more than 61% year-to-date. The stock climbed to new 52-week highs on Monday, according to <a href="https://pro.benzinga.com/dashboard?new_user=False&amp;backend=google-oauth2">Benzinga Pro</a>.
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Zscaler Shares Hit New 52-Week High: What's Driving The Momentum?

<ul class="wp-block-list">
<li>The U.S. has the largest number of high-net-worth individuals, according to a new report from Henley &amp; Partners and New World Health</li>
<li>37% of the global millionaire population, 36% of the world's centimillionaires, and 33% of billionaires call the country home</li>
<li>These ultra-wealthy individuals primarily live in or near major cities like New York, San Francisco, and Los Angeles</li>
</ul>
The U.S. is home to 37% of the global millionaire total, according to a new report from Henley &amp; Partners and New World Wealth.
The <a href="https://www.henleyglobal.com/newsroom/press-releases/usa-wealth-report-2025">USA Wealth Report</a> says that over 6 million high net worth individuals, defined as those with investable assets of $1 million or more, resided in the U.S. at the end of 2024. Additionally, 36% of the world's centimillionaires and 33% of the world's billionaires also call the country home.
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Over the past decade, the U.S. has seen its millionaire population increase by 78%. This growth slightly outpaces China, which saw its millionaire population increase by 74% between 2014 and 2024, and well outpaces other wealthy countries like Japan (5%), Canada (26%), Switzerland (28%), and the UK (-9%).&nbsp;
Tim Klatte, partner at Grant Thornton China, warns high net worth individuals that despite this incredible growth rate, they shouldn't get too comfortable. "The U.S.–China trade war is more than an economic battle — it is a complex geopolitical contest with far-reaching consequences," he said in a statement accompanying the report. "HNW investors must account for the risk of escalating tensions, potential breakdowns in trade negotiations, and the broader threat of international conflict. These geopolitical dynamics can significantly influence investment decisions, asset allocation, and long-term wealth preservation."
Trending: Invest where it hurts — and help millions heal:<a href="https://www.benzinga.com/money/a-cure-for-osteoarthritis-powered-by-everyday-investors-cytonics-is-looking-to-beat-big-pharma-and-disrupt-a-390-billion-market"> Invest in Cytonics and help disrupt a $390B Big Pharma stronghold</a>.
In fact, this economic unrest has led many ultra-wealthy Americans to explore their options when it comes to moving their wealth outside the US. According to the report, US citizens account for over 30% of all investment migration applications submitted through Henley &amp; Partners at this point in the year. A number that is nearly double the combined total of the next five investor nationalities, which include Turkish, Indian, and British.
"We're witnessing a new level of sophistication in how affluent Americans manage and diversify their wealth," says Basil Mohr-Elzeki, managing partner at Henley &amp; Partners North America. "Securing alternative residences and citizenships is now a strategic form of risk management — a thoughtful ‘Plan B' that enhances family resilience, unlocks global opportunities, and safeguards multigenerational legacies."
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Within the U.S., high net worth individuals tend to congregate in areas the report calls "urban wealth hubs." New York City has the highest number of high net worth individuals, with 384,500 millionaires, 818 centimillionaires, and 66 billionaires. The San Francisco Bay Area, which includes Silicon Valley, is second with 342,400 millionaires, 756 centimillionaires, and 82 billionaires. Los Angeles, Chicago, and Dallas round out the top five.
"Despite a wave of policy changes and their subsequent implications around the world, the relative political stability, rule of law, economic prospects, culture of innovation, not to mention the US dollar remaining the global reserve currency, have squarely positioned the USA as an environment in which to do business and to invest," said David K. Young, president at the Committee for Economic Development of The Conference Board in a statement accompanying the report.
Read Next: <a href="https://www.benzinga.com/money/are-you-rich">Are you rich?</a> Here&#8217;s what Americans think you need to be considered wealthy.
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Personal Finance

37% Of The World's Millionaires Call The US Home, Up 78% Over The Last Decade

RIVN

Rivian Automotive shares are trading lower after the company announced a proposed $1.25 billion senior secured green notes offering.

Scotiabank analyst Louise Chen downgrades Blueprint Medicines (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BPMC#NASDAQ">BPMC</a>) from Sector Outperform to Sector Perform and announces $135 price target.

Downgrades

BPMC

Scotiabank Downgrades Blueprint Medicines to Sector Perform, Announces $135 Price Target

CGAU

RGLD

SSRM

USAU

Shares of precious metals stocks are trading higher as gold and silver prices rise amid dollar weakness.

JP Morgan analyst Brian Cheng downgrades Blueprint Medicines (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BPMC#NASDAQ">BPMC</a>) from Overweight to Neutral and lowers the price target from $130 to $129.

JP Morgan Downgrades Blueprint Medicines to Neutral, Lowers Price Target to $129

<a href="https://www.benzinga.com/markets/cryptocurrency/25/03/44300120/binance-ceo-richard-teng-hails-donald-trumps-bitcoin-reserve-xrp-ethereum-solana-digital-asset-stockpile">Binance CEO Richard Teng</a> on Monday said the United States is &#8220;firmly back in the driver's seat&#8221; to lead the global crypto industry, following a major regulatory development that saw U.S. authorities drop a lawsuit against the crypto exchange and its founder Changpeng Zhao.
What Happened: "This is a significant win not just for Binance, but for the entire industry," Teng said during an <a href="https://www.cnbc.com/video/2025/06/02/binance-ceo-richard-teng-on-sec-suit-dismissal-trump-meme-coin-and-crypto-regulation.html?__source=sharebar&#x7C;twitter&amp;par=sharebar">interview</a> with CNBC. "The U.S. is firmly back in the driver's seat to become the crypto hub of the world."
Teng credited the shift to the regulatory approach taken by the current administration, praising what he called a "considerate and thoughtful" stance that favors regulatory clarity over enforcement-first tactics.
The CFTC's original complaint had accused Binance of allowing illegal access to U.S. users, inflating trading volumes, and co-mingling customer funds. 
Its dismissal now marks a turning point in the broader U.S. regulatory landscape, according to the CEO.
Looking ahead, Teng expressed optimism about bipartisan efforts to create clear rules for the industry, stating that greater clarity will benefit investors, companies and regulators alike.
Also Read: <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/45718017/nothing-stops-this-train-us-fiscal-deficits-drive-bitcoins-case-as-a-hedge-says-lyn-alden">&#8216;Nothing Stops This Train&#8217;: US Fiscal Deficits Drive Bitcoin&#8217;s Case As A Hedge, Says Lyn Alden</a>
"We are deeply supportive of a regulatory framework that protects users," he said, citing Binance's milestone of surpassing 275 million global users.
Teng also addressed concerns over the proliferation of meme coins tied to political figures like President Donald Trump. 
While avoiding direct comment on their legitimacy, Teng emphasized the decentralized and permissionless nature of token creation in crypto.
Beyond the legal developments, Teng highlighted Binance's growing compliance infrastructure. 
The platform now employs over 1,400 people in its compliance division and is regulated in more than 22 countries.
"We are the most regulated global platform today," Teng said. "Our focus is on security, compliance, and user protection."
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Cryptocurrency

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Moderna, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRNA#NASDAQ">MRNA</a>) shares are trading higher Monday after the company announced its new COVID-19 vaccine secured clearance from the U.S. Food and Drug Administration (FDA) for seniors and <a href="https://www.benzinga.com//node/45708511">at-risk individuals.</a>
What To Know: In a Phase 3 clinical trial, the new vaccine, mNEXSPIKE, showed a higher vaccine efficacy as well as a similar safety profile compared to the company&#8217;s original COVID-19 vaccine. 
&#8220;The FDA approval of our third product, mNEXSPIKE, adds an important new tool to help protect people at high risk of severe disease from COVID-19,&#8221; said Stéphane Bancel, CEO of Moderna.
&#8220;COVID-19 remains a serious public health threat, with more than 47,000 Americans dying from the virus last year alone. We appreciate the FDA&#8217;s timely review and thank the entire Moderna team for their hard work and continued commitment to public health.&#8221;
Moderna expects to have mNEXSPIKE available for eligible populations in the U.S. for the 2025-2026 respiratory virus season. The new vaccine is under review with regulators in multiple markets around the world.
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MRNA Price Action: At the time of writing, Moderna stock is trading 2.73% higher at $27.28, according to data from <a href="https://pro.benzinga.com/">Benzinga Pro.</a>
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MRNA

Moderna Stock Is Trading Higher Monday: What's Going On?

As crypto adoption continues to grow, how individuals trade, not what they trade, has become the focus. While centralized platforms remain popular for convenience, they expose traders to more risk than is necessary.
More investors are looking for how to maintain full control of their crypto assets while minimizing exposure to third parties. One solution is necessary, decentralized crypto swaps, for example exchanging BTC for USDT. &nbsp;&nbsp;
The Problem with Centralized Swap Brokers
Most wallet-based swap interfaces, software or hardware, use centralized intermediary brokers to process transactions at present.
While the services are quick and convenient, they also expose:
• Counterparty risk, Funds are in the control of a third party temporarily during the swap.
• Privacy trade-offs, KYC requirements can force users to reveal sensitive personal information.
• Higher fees and slippage, Centralized services are more costly than decentralized alternatives.
For security-minded traders and long-term investors, these compromises are becoming ever harder to make.
Why Decentralized Swaps Offer a Better Alternative
Protocols that facilitate decentralized trading infrastructure, and wallet-to-wallet transactions without surrendering custody or personal data are the future.
Such solutions should also:
• Reduce reliance on any one central authority,
• Improve fee transparency and access to greater liquidity,
• More accurately reflect the underlying basis of crypto, decentralization and user sovereignty
Other wallet providers are beginning to recognize the value of natively embedding such decentralized protocols on their platforms, and user demand is only growing.
A Quantum Threat to Security Is on the Horizon
In addition to swap risk, another long-term problem is now taking shape, quantum computing.
Some experts, including venture capitalist Chamath Palihapitiya, are sounding the alarm that quantum developments can arrive as soon as 5 to 10 years from now, with the potential to break the encryption that safeguards today&#8217;s digital assets.
While it remains one of the most secure ways to hold crypto, exposure during swaps, especially with third parties, could be an entry point of vulnerability in the future.
Security-aware users are already adopting best practices such as:
• Never using the same exact address for multiple transactions. Use a wallet that generates a new one each time.
• Minimizing exposure to third-party custodians,
• Utilizing wallets and protocols that support decentralized infrastructure
As quantum abilities reach maturity, decentralization will not just enhance privacy and autonomy but may also turn into a default line of defense.
The Bottom Line
Integrating decentralized swap protocols into wallet ecosystems isn&#8217;t just a UX enhancement, it&#8217;s a long-term move towards privacy, affordability, and improved personal security.
For cryptocurrency traders wanting to stay ahead of both market risk and technological developments, solutions that adopt underlying decentralized principles are more important than ever.
The author has an investment in BTC.
&#x2A;&#x2A;
We at <a href="https://cryptoflowzone.com/">https://cryptoflowzone.com/</a> will continue to monitor and evaluate developments in this space to help traders make the correct choices. We also expect to pressure cold wallet providers to develop decentralized swap protocols within their solution, and offer investors a safer way of broadcast transacting in the future. Keep your eyes on the prize and Trade safe.

Opinion

Why Decentralized Swaps Are The Next Frontier For Secure Crypto Trading

Piper Sandler analyst Paul Newsome initiated coverage on Aspen Insurance Holdings Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AHL#NYSE">AHL</a>) with an Overweight rating and <a href="https://www.benzinga.com/quote/ahl/analyst-ratings" target="_blank" rel="noreferrer noopener">price target of $40</a>.
The company&#8217;s IPO took place on May 8 on the NYSE exchange and it offered shares at a price of $30 per share with an insider lock-up period of 180 days<a href="https://www.benzinga.com//node/45329236" target="_blank" rel="noreferrer noopener"> that ends on November 04, 2025</a>.
The analyst writes that AHL is a reasonably profitable specialty insurer and reinsurer and he anticipates a recently completed business transformation to facilitate future growth and improved profitability.
Newsome notes that the company underwent a significant restructuring following its acquisition by Apollo in 2019.
The analyst adds that despite divesting approximately 17 business lines across its insurance and reinsurance segments, the company has reported notable improvements in its underwriting profitability and Gross Written Premium (GWP) growth.
The analyst highlights that this transformation has reduced volatility in its underwriting performance. Also, operating Return on Equity (ROE) reached 19.4% in 2024, with a three-year average of 17.1%.
Moreover, the company has seen substantial gains in underwriting profitability, and the combined ratio improved from 98.8% in 2021 to 88.0% in 2024, according to the analyst.
Newsome says that this enhanced underwriting performance is primarily attributed to a reduction in the expense ratio, an improving underlying loss ratio, and better management of catastrophe loss risks.
Overall, the analyst believes that the company warrants a slight premium valuation compared to its reinsurance peer group, given that its specialty business accounts for approximately 60% of its gross written premiums.
The analyst estimates the EPS of $3.61 for FY25 and $4.97 for FY26.
Price Action: AHL shares are up 0.81% at $34.69  at the last check on Monday.
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Initiation

Aspen Insurance Emerges From Turnaround With Momentum: Analyst Sees More Upside Ahead

<a href="https://www.chicagofed.org/publications/speeches/2025/june-2-quad-cities-business-journal" title="https://www.chicagofed.org/publications/speeches/2025/june-2-quad-cities-business-journal">https://www.chicagofed.org/publications/speeches/2025/june-2-quad-cities-business-journal</a>

Macro Economic Events

Economics

Federal Reserve

Fed's Goolsbee Says Recent PCE Inflation Print May Have Been 'Last Vestige' Of Pre-Tariff Impact

Oppenheimer analyst Andreas Argyrides assumes Harmony Biosciences Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HRMY#NASDAQ">HRMY</a>) with a Outperform rating and announces Price Target of $61.

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AstraZeneca Plc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AZN#NASDAQ">AZN</a>) on Monday released results from <a href="https://www.benzinga.com/general/health-care">three Phase 3 clinical trials</a> at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting: DESTINY-Breast09, MATTERHORN, and SERENA-6.
In the DESTINY-Breast09 trial, Enhertu (trastuzumab deruxtecan) combined with pertuzumab was evaluated as a first-line treatment for HER2-positive metastatic breast cancer, compared to a standard regimen of a taxane, trastuzumab, and pertuzumab (THP). 
Topline data <a href="https://www.benzinga.com/general/biotech/25/04/44894989/astrazeneca-daiichi-sankyos-multi-billion-dollar-cancer-drug-shows-superior-efficacy-across-broad" target="_blank" rel="noreferrer noopener">were shared in April</a>.
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Results indicated that the <a href="https://www.astrazeneca.com/media-centre/press-releases/2025/enhertu-plus-pertuzumab-reduced-the-risk-of-disease-progression-or-death-vs-thp-as-1st-line-therapy-in-patients-with-her2-positive-metastatic-breast-cancer.html">Enhertu</a> combination reduced the risk of disease progression or death by 44%. Median progression-free survival (PFS) reached 40.7 months with the Enhertu regimen versus 26.9 months for THP, a benefit observed across patient subgroups.
Investigator-assessed median PFS was 40.7 months for the Enhertu arm and 20.7 months for THP. The confirmed objective response rate was 85.1% for the Enhertu combination and 78.6% for THP, with 58 complete responses in the Enhertu group compared to 33 with THP. 
The median duration of response was 39.2 months for the Enhertu combination and 26.4 months for THP. Overall survival data was not yet mature, though an early trend favored the Enhertu combination.
The MATTERHORN trial assessed <a href="https://www.astrazeneca-us.com/media/press-releases/2025/IMFINZI-durvalumab-regimen-reduced-risk-of-progression-recurrence-or-death-by-29-percent-in-early-stage-gastric-cancer-vs-chemotherapy-alone-in-MATTERHORN-Phase-III-trial.html?utm_source=external-comms&amp;utm_medium=memo&amp;utm_campaign=asco2025&amp;utm_term=corporate&amp;utm_content=matterhorn">Imfinzi</a> (durvalumab) with standard FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) chemotherapy as a perioperative treatment for resectable, early-stage, and locally advanced gastric and gastroesophageal junction (GEJ) cancers, compared to chemotherapy alone.
Topline data <a href="https://www.benzinga.com/general/biotech/25/03/44188407/astrazenecas-imfinzi-based-regimen-shows-improved-event-free-survival-in-early-stage-gastric-canc" target="_blank" rel="noreferrer noopener">were released in March</a>.
A planned interim analysis showed that the Imfinzi-based regimen led to a 29% reduction in the risk of disease progression, recurrence, or death. 
Median event-free survival (EFS) was not reached in the Imfinzi arm, compared to 32.8 months in the chemotherapy-alone arm. The estimated 24-month EFS rate was 67.4% for the Imfinzi regimen and 58.5% for chemotherapy alone. 
A trend towards improved overall survival was noted for the Imfinzi-based regimen, with formal assessment to follow.
The SERENA-6 trial investigated <a href="https://www.astrazeneca-us.com/media/press-releases/2025/Camizestrant-reduced-the-risk-of-disease-progression-or-death-by-56-in-patients-with-advanced-HR-positive-breast-cancer-with-an-emergent-ESR1-tumor-mutation-in-SERENA-6-Phase-III-trial.html?utm_source=external-comms&amp;utm_medium=memo&amp;utm_campaign=asco2025&amp;utm_term=corporate&amp;utm_content=serena-6">camizestrant</a> combined with a cyclin-dependent kinase (CDK) 4/6 inhibitor (palbociclib, ribociclib or abemaciclib) in patients with hormone receptor (HR)-positive, HER2-negative advanced breast cancer whose tumors developed an ESR1 mutation during first-line treatment with an aromatase inhibitor (AI) and a CDK4/6 inhibitor.
Topline data were <a href="https://www.benzinga.com/25/02/43975577/astrazenecas-investigational-cancer-drug-shows-first-line-benefit-in-combination-with-widely-cancer-medicines" target="_blank" rel="noreferrer noopener">shared in February</a>.
The trial compared switching to the camizestrant combination against continuing the AI plus CDK4/6 inhibitor. The camizestrant combination reduced the risk of disease progression or death by 56%. 
Median PFS was 16.0 months for patients who switched, versus 9.2 months for those continuing the AI combination. The median time to deterioration of global health status was 23.0 months for the camizestrant arm and 6.4 months for the AI combination arm. 
While data for time to second disease progression and overall survival were immature, a trend favored the camizestrant combination for PFS2.
Price Action: AZN stock is trading lower by 0.95% at $72.14 at last check Monday.
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